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title: Automation of the Hereditary Cancer Solution by SOPHiA GENETICS on Hamilton STARlet
description: The Hereditary Cancer Solution (HCS) by SOPHiA GENETICS is the first capture-based application, whit the CE-IVD mark. It is frequently requested in the field, especially in the clinical environment where minimizing human intervention is a plus, for standardization of genomic testing in clinical settings
---

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![Automation-of-the-Hereditary-Cancer-Solution-app-note.jpg](https://robotics.hamiltoncompany.com/hs-fs/hubfs/Automation-of-the-Hereditary-Cancer-Solution-app-note.jpg?width=2000&name=Automation-of-the-Hereditary-Cancer-Solution-app-note.jpg "Automation-of-the-Hereditary-Cancer-Solution-app-note.jpg")

# Automation of the Hereditary Cancer Solution by SOPHiA GENETICS on a STARlet

Download our new Application Note about the automation of the HCS by SOPHiA GENETICS, the first capture-based application, which has received the CE-IVD mark.

This protocol is frequently requested in the field, especially in the clinical environment where minimizing human intervention is a plus.

During this validation study, all confirmed variants (SNVs and Indels) were reliably called and all CNVs have been detected, including gene conversion events in PMS2/PMS2CL.

This app note describes the automation of 2 protocol steps, whole genome library preparation & target capture, with Pre & Post-PCR workflows performed on the same deck layout.

[![Down Arrow](https://cdn2.hubspot.net/hubfs/2684535/Alande/down-arrow.png) ](https://robotics.hamiltoncompany.com/automation-of-the-hereditary-cancer-solution-sophia-genetics#information-product)

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![sophia-genetics-standardization.png](https://robotics.hamiltoncompany.com/hs-fs/hubfs/sophia-genetics-standardization.png?width=80&name=sophia-genetics-standardization.png "sophia-genetics-standardization.png")

#### Standardization of genomic testing in clinical settings

![sophia-genetics-reduction-of-bias.png](https://robotics.hamiltoncompany.com/hs-fs/hubfs/sophia-genetics-reduction-of-bias.png?width=70&name=sophia-genetics-reduction-of-bias.png "sophia-genetics-reduction-of-bias.png")

#### Reduction of bias due to manual sample preparation

![sophia-genetics-ngs-application.png](https://robotics.hamiltoncompany.com/hs-fs/hubfs/sophia-genetics-ngs-application.png?width=80&name=sophia-genetics-ngs-application.png "sophia-genetics-ngs-application.png")

#### A comprehensive NGS application for the detection of genomic variants

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